Action and Function of Neutrophils in Crohn`s Disease .pdf

Action and Function of Neutrophils in Crohn`s Disease
Rajesh Somasundaram

CONTENTS
Chapter 1 General introduction and scope of the thesis
Chapter 2 Impact of human granulocyte and monocyte isolation procedures on functional studies
Chapter 3 Altered cell signalling and neutrophil functions in Crohn`s disease with skin manifestation
Chapter 4 Linking risk conferring mutations in NCF4 to functional consequences in Crohn`s disease
Chapter 5 Defective GM-CSF signalling in granulocytes from Crohn`s disease patients carrying the NCF4 risk-allele
Chapter 6 Adding fuel to the fire: acquisition of antigen presenting cell characteristics by mucosal
granulocytes from patients with Crohn`s disease
Chapter 7 Maintaining spontaneous and pharmacologically induced remission in Crohn`s disease by active suppression of p21Rac1 signalling
Chapter 8 Decreased SHIP-1 activity in Crohn`s disease
Chapter 9 Summary and discussion
List of publications
Acknowledgements