MultiPatch 1.4 - Patch NDS files on Mac

MultiPatch is an all-in-one file patching solution. With this one program, you can apply IPS, UPS, PPF, XDelta, BSDiff, or BPS patches to files. You can also create IPS, UPS, XDelta, BSDiff or BPS patches. Everything is contained in one application, it is not a front-end and thus does not need to rely on external tools to accomplish the job. This program is a universal binary for any Mac running Mac OS X 10.7 or later.

Source: http://projects.sappharad.com/tools/multipatch.html