Synedoche, New York - Screenplay by Charlie Kaufman

Writer bio.: "Charles Stuart "Charlie" Kaufman (born November 19, 1958) is an American screenwriter, producer, and director. His works include Being John Malkovich, Human Nature, Adaptation, Eternal Sunshine of the Spotless Mind and Synecdoche, New York. He won the Academy Award for Best Original Screenplay for Eternal Sunshine of the Spotless Mind."

The text: Theatre director Caden Cotard[4] (Philip Seymour Hoffman) finds his life unraveling. Suffering from numerous physical ailments and growing increasingly alienated from his wife, Adele (Catherine Keener), he hits bottom when Adele leaves him for a new life in Berlin, taking their daughter, Olive (Sadie Goldstein/​Robin Weigert), with her.
Shortly afterward, Caden unexpectedly receives a MacArthur Fellowship, giving him the financial means to pursue his artistic interests. He is determined to use it to create an artistic piece of brutal realism and honesty, something into which he can pour his whole self. Gathering an ensemble cast into an enormous warehouse in Manhattan's theater district, he directs them in a celebration of the mundane, instructing each to live out their constructed lives. As the mockup inside the warehouse grows increasingly mimetic of the city outside, Caden continues to look for solutions to his personal crises. He is traumatized as he discovers Adele has become a celebrated painter in Berlin and Olive is growing up under the questionable guidance of Adele's friend, Maria (Jennifer Jason Leigh). After a disastrous fling with the woman who mans the box office, Hazel (Samantha Morton), he marries Claire (Michelle Williams), an actress in his cast. Their relationship ultimately fails, however, and he continues his awkward relationship with Hazel, who is by now married with children. Meanwhile, an unknown condition is systematically shutting down his autonomic functions one by one.
As the years rapidly pass, the continually expanding warehouse is isolated from the deterioration of the city outside. Caden buries himself ever deeper into his magnum opus, blurring the line between the world of the play and that of reality by populating the cast and crew with doppelgängers. For instance, Sammy Barnathan (Tom Noonan) is cast in the role of Caden in the play after Sammy reveals that he has been obsessively following Caden for 20 years, while Sammy's lookalike is cast as Sammy. Sammy's own interest in Hazel sparks a revival of Caden's relationship with her.
As he pushes the limits of his relationships personally and professionally, Caden lets an actress take over his role as director and takes her previous role as Adele's cleaning lady. He lives out his days in the model of Adele's apartment under the replacement director's instruction during which some unexplained (and likely in-universe) calamity occurs in the warehouse leaving ruins and bodies in its wake. Finally he prepares for death as he rests his head on the shoulder of an actress in the play, seemingly the only person left alive in the warehouse. As the scene fades to white, Caden says that now he has an idea for how to do the play, when the director's voice in his ear gives him his final cue: "Die."

Information extracted from Wikipedia