The Biology of Cancer 2nd Ed. (2013) - R.A. Weinberg.pdf

Book Summary

Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world.

The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology.

The new Second Edition has been comprehensively revised and updated to include major advances in cancer biology over the past six years. Updates include current information on:

The tumor microenvironment
Metastatic dissemination
Tumor immunology
Cancer stem cells
The epithelial-mesenchymal transition
Multi-step tumorigenesis
Invasion and metastasis
Mutation of cancer cell genomes
Greatly expanded treatment of traditional therapy
Epigenetic contributions
MicroRNA involvement
The Warburg effect

Besides its value as a textbook, The Biology of Cancer is a useful reference for individuals working in biomedical laboratories and for clinical professionals.

CONTENTS

1. The Biology and Genetics of Cells and Organisms
2. The Nature of Cancer
3. Tumor Viruses
4. Cellular Oncogenes
5. Growth Factors, Receptors, and Cancer
6. Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer
7. Tumor Suppressor Genes
8. pRb and Control of the Cell Cycle Clock
9. p53 and Apoptosis: Master Guardian and Executioner
10. Eternal Life: Cell Immortalization and Tumorigenesis
11. Multi-step Tumorigenesis
12. Maintenance of Genomic Integrity and the Development of Cancer
13. Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis
14. Moving Out: Invasion and Metastasis
15. Crowd Control: Tumor Immunology and Immunotherapy
16. The Rational Treatment of Cancer

Reviews

"The book fulfills its purpose and is, indeed, a must-read for students of cancer biology…It includes updated information and concepts in cancer research that justify replacing the previous edition."
- Doody Reviews

"This publication represents an exhaustive and detailed coverage of the field of basic oncology oriented toward a student audience, and it continues to set the highest example of excellence in the field of undergraduate and graduate oncology." - The Quarterly Review of Biology

"Clearly, not only is it an authoritative text book on the complex biology of cancer, it serves as an invaluable reference document for individuals working in biomedical laboratories as well as professionals involved in day to day management of cancer in the clinics." - Oncology News

Praise for the First Edition of THE BIOLOGY OF CANCER by Robert A. Weinberg:

“There is no comparable text in cancer biology…”
- Nature

“The Biology of Cancer is no doubt the definitive statement on its topic today.”
- Science

“Here, at last, we have a definitive textbook specifically devoted to the molecular and cell biology of cancer.”
- Bioscience Education

“Overall, this is a remarkable achievement that is by far the most comprehensive coverage of this field available.”
- Times Higher Education Supplement