The scientific basis of stem cell therapy in IBD.pdf

The scientific basis of stem cell therapy in IBD
Daniel Hommes
HSCT in autoimmune disease leads to an immune renewal, truly resetting the adaptive immune system
1. Increased frequency of phenotypically naïve CD4+ T cells
2. Decreased frequency of central-memory T cells
3. Expansion of CD4+ RTEs (recent thymic emigrants)
4. Increased TREC levels in CD4+ cells
5. Improved clonal diversity of the TCR repertoire
6. Extensive clonotypic renewal shown by comparing pre- and posttherapy TCR transcripts
47 pages