TYPE 1 DIABETES PATHOGENESIS GENETICS AND IMMUNOTHERAPY .pdf

TYPE 1 DIABETES PATHOGENESIS GENETICS AND IMMUNOTHERAPY
Edited by David Wagner

This book is a compilation of reviews about the pathogenesis of Type 1 Diabetes. T1D is a classic autoimmune disease. Genetic factors are clearly determinant but cannot explain the rapid, even overwhelming expanse of this disease. Understanding etiology and pathogenesis of this disease is essential. A number of experts in the field have covered a range of topics for consideration that are applicable to researcher and clinician alike. This book provides apt descriptions of cutting edge technologies and applications in the ever going search for treatments and cure for diabetes. Areas including T cell development, innate immune responses, imaging of pancreata, potential viral initiators, etc. are considered.

The compilation is provided by INTECH Type 1 Diabetes - Pathogenesis, Genetics and Immunotherapy under an open access license (CC BY 3.0 license), You are free to: Share — copy and redistribute the material in any medium or format, Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms.

Content

Chapter 1 Autoimmunity and Immunotherapy of Type 1 Diabetes by Mourad Aribi
Chapter 2 Use of Congenic Mouse Strains for Gene Identification in Type 1 Diabetes by Ute Christine Rogner
Chapter 3 Relationship of Type 1 Diabetes with Human Leukocyte Antigen (HLA) Class II Antigens Except for DR3 and DR4 by Masahito Katahira
Chapter 4 The Role of T Cells in Type 1 Diabetes by David Wagner
Chapter 5 Beta-Cell Function and Failure in Type 1 Diabetes by Maria-Luisa Lazo de la Vega-Monroy and Cristina Fernandez-Mejia
Chapter 6 Steady-State Cell Apoptosis and Immune Tolerance - Induction of Tolerance Using Apoptotic Cells in Type 1 Diabetes and Other Immune-Mediated Disorders by Chang-Qing Xia, Kim Campbell, Benjamin Keselowsky and Michael Clare-Salzler
Chapter 7 Innate Immunity in the Recognition of β-Cell Antigens in Type 1 Diabetes by Jixin Zhong, Jun-Fa Xu, Ping Yang, Yi Liang and Cong-Yi Wang
Chapter 8 The Role of Reg Proteins, a Family of Secreted C-Type Lectins, in Islet Regeneration and as Autoantigens in Type 1 Diabetes by Werner Gurr
Chapter 9 Type I Diabetes and the Role of Inflammatory-Related Cellular Signaling by Lloyd Jesse, Kelleher Andrew, Choi Myung and Keslacy Stefan
Chapter 10 Echovirus Epidemics, Autoimmunity, and Type 1 Diabetes by Oscar Diaz-Horta, Luis Sarmiento, Andreina Baj, Eduardo Cabrera-Rode and Antonio Toniolo
Chapter 11 Environmental Triggers of Type 1 Diabetes Mellitus – Mycobacterium Avium Subspecies Paratuberculosis by Coad Thomas Dow and Leonardo A. Sechi
Chapter 12 In Vivo Monitoring of Inflammation and Regulation in Type 1 Diabetes by Mi-Heon Lee, Sonya Liu, Wen-Hui Lee and Chih-Pin Liu
Chapter 13 Imaging the Pancreatic Beta Cell by Ulf Ahlgren and Elena Kostromina
Chapter 14 Present Accomplishments and Future Prospects of Cell-Based Therapies for Type 1 Diabetes Mellitus by Preeti Chhabra, Clark D. Kensinger, Daniel J. Moore and Kenneth L. Brayman
Chapter 15 Peptides and Proteins for Treatment and Suppression of Type 1 Diabetes by Ahmed H. Badawi, Barlas Büyüktimkin, Paul Kiptoo and Teruna J. Siahaan
Chapter 16 Immunotherapy for Type 1 Diabetes – Preclinical and Clinical Trials by Alice Li and Alan Escher
Chapter 17 Type 1 Diabetes Immunotherapy - Successes, Failures and Promises by Brett E. Phillips and Nick Giannoukakis
Chapter 18 Immunotherapy for Type 1 Diabetes - Necessity, Challenges and Unconventional Opportunities by Rachel Gutfreund and Abdel Rahim A. Hamad
Chapter 19 Autoantigen-Specific Immunotherapy by Shuhong Han, William Donelan, Westley Reeves and Li-Jun Yang
Chapter 20 Multi-Component Vaccines for Suppression of Type 1 Diabetes by William H.R. Langridge and Oludare J. Odumosu
Chapter 21 Porcine Islet Xenotransplantation for the Treatment of Type 1 Diabetes by Dana Mihalicz, Ray V. Rajotte and Gina R. Rayat
Chapter 22 Beta Cell Replacement Therapy by Jeffrey A. SoRelle and Bashoo Naziruddin
Chapter 23 Genetics of Type 1 Diabetes by Tatijana Zemunik and Vesna Boraska
Chapter 24 The Genetics of Type 1 Diabetes by Kathleen M. Gillespie
Chapter 25 Comparative Genetic Analysis of Type 1 Diabetes and Inflammatory Bowel Disease by Marina Bakay, Rahul Pandey and Hakon Hakonarson
Chapter 26 Genetics of Type 1 Diabetes by Marie Cerna
Chapter 27 Genetic Markers, Serological Auto Antibodies and Prediction of Type 1 Diabetes by Raouia Fakhfakh
Chapter 28 Genetic Determinants of Type 1 Diabetes by Mohamed M. Jahromi