Freshman Organic Chemistry with J. Michael McBride - Yale Online Course Video Lectures

Freshman Organic Chemistry Yale Course , Fall 2008 , Prof. J. Michael McBride

Lecture Details :
Professor McBride outlines the course with its goals and requirements, including the required laboratory course. To the course's prime question "How do you know" he proposes two unacceptable answers (divine and human authority), and two acceptable answers (experiment and logic). He illustrates the fruitfulness of experiment and logic using the rise of science in the seventeenth century. London's Royal Society and the "crucial" experiment on light by Isaac Newton provide examples. In his correspondence with Newton Samuel Pepys, diarist and naval purchasing officer, illustrates the attitudes and habits which are most vital for budding scientists - especially those who would like to succeed in this course. The lecture closes by introducing the underlying goal for the first half of the semester: understanding the Force Law that describes chemical bonds.
Course Description :
This is the first semester in a two-semester introductory course focused on current theories of structure and mechanism in organic chemistry, their historical development, and their basis in experimental observation. The course is open to freshmen with excellent preparation in chemistry and physics, and it aims to develop both taste for original science and intellectual skills necessary for creative research.

Lectures INDEXHow Do You Know?Force Laws, Lewis Structures and ResonanceDouble Minima, Earnshaws Theorem and Plum-PuddingsCoping with Smallness and Scanning Probe MicroscopyX-Ray DiffractionSeeing Bonds by Electron Difference DensityQuantum Mechanical Kinetic EnergyOne-Dimensional Wave FunctionsChladni Figures and One-Electron AtomsReality and the Orbital ApproximationOrbital Correction and Plum-Pudding MoleculesOverlap and Atom-Pair BondsOverlap and Energy-MatchChecking Hybridization Theory with XH_3Chemical Reactivity: SOMO, HOMO, and LUMORecognizing Functional GroupsReaction Analogies and Carbonyl ReactivityAmide, Carboxylic Acid and Alkyl LithiumOxygen and the Chemical RevolutionRise of the Atomic TheoryBerzelius to Liebig and W�hlerRadical and Type Theories (1832-1850)Valence Theory and Constitutional Structure (1858)Determining Chemical Structure by Isomer Counting (1869)Models in 3D Space (1869-1877); Optical IsomersVant Hoffs Tetrahedral Carbon and ChiralityCommunicating Molecular Structure in Diagrams and WordsStereochemical Nomenclature; Racemization and ResolutionPreparing Single Enantiomers and the Mechanism of Optical RotationEsomeprazole as an Example of Drug Testing and UsagePreparing Single Enantiomers and Conformational EnergyStereotopicity and Baeyer Strain TheoryConformational Energy and Molecular MechanicsSharpless Oxidation Catalysts and the Conformation of CycloalkanesUnderstanding Molecular Structure and Energy through Standard BondsBond Energies, the Boltzmann Factor and EntropyPotential Energy Surfaces, Transition State Theory and Reaction Mechanism

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